Breast cancer treatment often involves reconstructive surgeries, which may use implants or tissue from other parts of the body. Researchers have now developed a preliminary injectable gel derived from human skin cells, which could help restore breast volume after tumor removal, with fewer scars and shorter recovery times.
How the Gel Works
Published in ACS Applied Bio Materials, the study, led by Pham Ngoc Chin, explains that the gel works by promoting blood vessel growth and tissue remodeling while maintaining low inflammation and reducing capsule contraction. This approach may make breast reconstruction safer, less invasive, and easier, improving both patient comfort and cosmetic outcomes.
Currently, breast cancer surgery often involves removing cancerous and damaged tissue, sometimes requiring complete mastectomy. To preserve breast volume, surgeons rearrange remaining tissue and may use skin and fat from other body areas, similar to skin grafting. However, these methods can leave scars at donor sites.
The Role of Decellularized Dermal Matrix (ADM)
The new approach uses decellularized dermal matrix (ADM)—skin treated to remove outer layers, leaving collagen, elastin, and growth factors that promote healing.
ADM is currently available as sheets for tendon repair or cosmetic surgeries. The South Korean research team developed a gel form suitable for injection, ideal for filling gaps in breast reconstruction.
Experimental Testing
Researchers processed skin samples donated by a living volunteer, removing cells, freezing, and grinding the tissue to create small ADM particles. Water was added to form a thick injectable paste, which was then tested in mice and compared with two commercial ADM products.
After six months, the mice showed no adverse health effects. Notably, tissue layers around the injected ADM gel were thinner than those treated with commercial products—a positive outcome, as thinner tissue layers in breast implants reduce the risk of complications like infections or hematomas.
Next Steps
While the results are promising, long-term safety studies and more complex trials are needed before the gel can be considered for clinical use in human breast reconstruction.
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